Inference for current leukemia free survival
نویسندگان
چکیده
منابع مشابه
Long-term disease-free survival in acute nonlymphocytic leukemia.
Twenty-six of 45 adults (58%) with acute nonlymphocytic leukemia who were treated with intensive induction chemotherapy over 5 yr ago entered complete remission. All patients entering remission were placed on weekly maintenance chemotherapy consisting of cytosine arabinoside and 6-thioguanine. The median duration of complete remission was 17 mo and 7 patients (27%) remained in their initial rem...
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introduction: acute myeloid leukemia (aml) is a clonal disease characterized by heterogeneous involvement of hematopoietic bone marrow cell populations. in aml patients, a variety of clinical and biologic parameters, including surface markers, have been examinedfor potential value in predicting treatment response and survival. by checking the myeloid, lymphoid and nonspecific markers on the bla...
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BACKGROUND The endpoints of progression-free survival (pfs) and time-to-progression (ttp) are frequently used to evaluate the clinical benefit of anticancer drugs. However, the surrogacy of those endpoints for overall survival (os) is not validated in all cancer settings. In the present study, we used a trial-based approach to assess the relationship between median pfs or ttp and median os in c...
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BACKGROUND In trials designed to evaluate new therapies for hematologic malignancies, end points such as leukemia-free survival are often used as surrogates for overall survival in acute leukemia. We aimed to assess whether leukemia-free survival is an acceptable statistical surrogate for overall survival when applied to remission maintenance therapy for acute myeloid leukemia. DESIGN AND MET...
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This article introduces a new Bayesian approach to the analysis of right-censored survival data. The hazard rate of interest is modeled as a product of conditionally independent stochastic processes, corresponding to (1) a baseline hazard function, and (2) a regression function representing the temporal innuence of the covariates. These processes jump at times that form time-homogeneous Poisson...
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ژورنال
عنوان ژورنال: Lifetime Data Analysis
سال: 2008
ISSN: 1380-7870,1572-9249
DOI: 10.1007/s10985-008-9093-1